by Cynthia M. Johnson, MA
Syphilis is a sexually transmitted infection (STI). If left untreated, syphilis can cause brain, nerve, and tissue damage. It can also cause death. It can be treated with antibiotics.
Syphilis is caused by bacteria. It is spread through contact with a syphilis sore. This may happen during vaginal, anal, or oral sex with an infected person
Risk Factors TOP
Factors that may raise your chance of getting syphilis are:
Symptoms will depend on what stage the syphilis is in. There are 3 main stages as well as a resting phase.
Primary Stage: 7 to 90 Days After Infection
A single sore appears. It will happen in the area where the infection was passed. Common sites are the external genitals, rectum, tongue, inside of the mouth, or lips.
It will start as a raised and painless sore called a chancre. It will break down to form an ulcer. It lasts for 3 to 6 weeks. The ulcer will heal on its own.
Without treatment, the infection may move to the secondary stage. This can happen even if you can’t see the ulcers anymore.
Secondary Stage: Several Weeks to Months after the Original Sore
This stage features a non-itchy rash. The rash may appear as rough, red, or reddish brown spots on the palms of the hands or soles of the feet. Other rashes may also appear in other places on the body. These rashes may appear as:
The rash may happen with flu-like symptoms, such as:
Without treatment, the symptoms will go away within a few weeks. But there may be repeated episodes during the next few years.
Latency (Resting) Stage: May Last for Years TOP
The infection is still present but there are no symptoms. It may or may not progress to the third stage. Blood tests for syphilis will be positive during this stage.
Tertiary (Third or Late) Stage TOP
This stage may starts years after the initial infection. This stage has become rare in developed countries. In this stage, the infection damages the:
Damage can be harsh enough to cause death. Symptoms are:
You will be asked about your symptoms and health history. A physical exam will be done.
You will have:
All people who have syphilis should also be tested for HIV.
Syphilis can be treated with antibiotics. The type of antibiotic and length of time you take it will depend on how long you have been infected.
If you have syphilis of any stage, avoid sexual contact until treatment is over and the infection is gone. Let your sex partners know. They will also need to be treated.
American Sexual Health Association
Centers for Disease Control and Prevention
Sex Information and Education Council of Canada
Bibbins-Domingo K, et al. Screening for syphilis infection in nonpregnant adults and adolescents: US Preventive Services Task Force recommendation statement. JAMA. 2016 Jun 7;315(21):2321-2327.
Latent syphilis. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T115040/Latent-syphilis . Updated May 9, 2018. Accessed August 2, 2018.
Primary syphilis. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T115619/Primary-syphilis . Updated May 9, 2018. Accessed August 2, 2018.
Secondary syphilis. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T113985/Secondary-syphilis . Updated May 9, 2018. Accessed August 2, 2018.
Syphilis-CDC fact sheet. Centers for Disease Control and Prevention website. Available at:
...(Click grey area to select URL)
Updated June 13, 2017. Accessed August 2, 2018.
Tertiary syphilis. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T113669/Tertiary-syphilis . Updated May 9, 2018. Accessed August 2, 2018.
Workowski KA, Berman S, Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines, 2010. MMWR 2010;59(No. RR-12):1-110.
Last reviewed May 2018 by EBSCO Medical Review Board Beverly Siegal, MD, FACOG
Last Updated: 8/2/2018
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
To send comments or feedback to our Editorial Team regarding the content please email us at email@example.com. Our Health Library Support team will respond to your email request within 2 business days.