Definition

Mononucleosis is a viral disease characterized by fever, sore throat, swollen lymph glands, and fatigue.

Swollen Glands Copyright © Nucleus Medical Media, Inc.

Causes

Mononucleosis is caused by the Epstein-Barr virus (EBV). Found mainly in saliva and mucus, EBV is passed from person to person by intimate behavior, such as kissing.

Risk Factors    TOP

Many people get EBV during their lifetime. Factors that increase the likelihood that EBV will develop into mononucleosis include:

• Contracting EBV after age 10
• Lowered immune resistance, due to other illness, stress, or fatigue
• Living in close quarters with a large number of people, such as in a college dormitory

One episode of mononucleosis usually produces permanent immunity.

Symptoms    TOP

Signs of mononucleosis usually begin 4-7 weeks after you were exposed to the virus. The initial symptoms may be a sense of general weakness that lasts about one week. This is followed by symptoms that may include:

• High fever
• Severe sore throat
• Swelling of the lymph nodes
• Fatigue
• Loss of appetite
• Muscle aches
• Enlargement of the spleen
• Swollen tonsils
• Mild jaundice

Diagnosis    TOP

Your doctor will ask about your symptoms and medical history. A physical exam will be done. Diagnosis is based on:

• Your age
• Four primary symptoms:
  • Fever
  • Swollen lymph nodes
  • Sore throat
  • Fatigue
• Two primary tests:
  • Blood tests and mono spot tests
  • Throat culture—to check for strep throat, which can complicate mono

Treatment    TOP

There is no treatment to cure mononucleosis or to shorten the length of the illness. It usually runs its course in 4-6 weeks, although the fatigue may last longer.

During the first few weeks after diagnosis, patients should avoid contact sports. Inflammation of the spleen from mononucleosis puts individuals at high risk of splenic rupture. This can require surgery, and in rare cases, can be fatal.

Treatment includes:

If you are diagnosed with mononucleosis, follow your doctor's instructions.

Prevention    TOP

Most people contract the EBV virus sometime during their lives. Prevention is geared toward decreasing the likelihood that EBV will develop into mononucleosis. Follow these guidelines to decrease your risk:

• Avoid intimate contact, especially kissing, with anyone who has active mononucleosis.
• Eat a healthful diet.
• Avoid excess stress.
• Get enough rest.