Vitamin D is both a vitamin and a hormone. It's a vitamin because your body cannot absorb calcium without it; it's a hormone because your body manufactures it in response to your skin's exposure to sunlight.
There are two major forms of vitamin D, and both have the word calciferol in their names. In Latin, calciferol means "calcium carrier." Vitamin D2 (ergocalciferol) and D3 (cholecalciferol) have similar actions in the body and can both be found in fortified food and supplements.
Strong evidence tells us that the combination of vitamin D and calcium supplements can be quite helpful for preventing and treating osteoporosis. Other potential uses of vitamin D have little supporting evidence.
Dosages of vitamin D are often expressed in terms of international units (IU) rather than milligrams. The Institute of Medicine's guidelines for Recommended Dietary Allowance are:108
These recommendations have recently been increased based on the latest evidence. For example, in a study of military personnel in submarines, use of 400 IU of vitamin D daily was inadequate to maintain bone health, while six days of sun exposure proved capable of supplying enough vitamin D for 49 sunless days.89 A study of veiled Islamic women living in Denmark found that 600 IU of vitamin D daily was insufficient to raise vitamin D levels in the blood to normal levels.1 The authors of this study recommend that sun-deprived individuals should receive 1,000 IU of vitamin D daily.
There is very little vitamin D found naturally in the foods we eat (the best sources are coldwater fish). In many countries, vitamin D is added to milk and other foods like breakfast cereals and margarine, contributing to our daily intake.
As indicated by the study of submarine personnel noted above, by far the best source of vitamin D is sunlight. However, current recommendations which stress sun avoidance and the use of sunblock may have the unintended effect of increasing the prevalence of vitamin D deficiency. Severe vitamin D deficiency was common in England in the 1800s due to coal smoke obscuring the sun. During that time, cod liver oil, which is high in vitamin D, became popular as a supplement for children to help prevent rickets. (Rickets is a disease caused by vitamin D deficiency in which developing bones soften and curve because they aren't receiving enough calcium.)
Vitamin D deficiency is known to occur today in the elderly (who often receive less sun exposure) as well as in people who live in northern latitudes and don't drink vitamin D-enriched milk.5,7 The consequences of this deficiency may be increased risk of hypertension, osteoporosis, and several forms of cancer.8
Additionally, phenytoin (Dilantin), primidone (Mysoline), and phenobarbital for seizures; corticosteroids; cimetidine (Tagamet) for ulcers; the blood-thinning drug heparin; and the antituberculosis drugs isoniazid (INH) and rifampin may interfere with vitamin D absorption or activity.9-27
Therapeutic Dosages TOP
For therapeutic purposes, vitamin D is taken at the nutritional doses described in Requirements/Sources (and sometimes in even higher amounts). If you wish to exceed nutritional levels of vitamin D intake, physician supervision is recommended (see Safety Issues).
Therapeutic Uses TOP
Without question, if you are concerned about osteoporosis, you should take calcium and vitamin D. The combination appears to help prevent bone loss.28,29 This is true even if you are taking other treatments for osteoporosis. After all, you can't build bone without calcium, and you can't properly absorb and utilize calcium without adequate intake of vitamin D.
Vitamin D may also help prevent the falls that lead to osteoporotic fractures. In a review of 26 randomized trials, researchers found that vitamin D along with calcium lowered the risk of falls in high-risk elderly people.111
Some evidence suggests that getting adequate vitamin D may help prevent cancer of the breast, colon, pancreas, prostate, and skin, but the research on this question has yielded mixed results.30-49,90,105 One study suggests that combined use of calcium plus vitamin D, but not either supplement separately, can help reduce risk of colon cancer.84 However, an extremely large study involving over 36,000 post-menopausal women found that supplementing the diet with 1,000 mg of calcium plus 400 IU of vitamin D daily did not lower the risk of breast cancer over a period of 7 years.106 Based on the results of this placebo-controlled study, there does not appear to be a connection between vitamin D and breast cancer risk.
Weak evidence hints that adequate vitamin D intake might reduce the risk of hypertension50-53,98 and diabetes.74-76 A very large randomized, placebo-controlled trial of over 36,000 postmenopausal women found daily supplementation with 1,000 mg of calcium plus 400 IU of vitamin D did not reduce or prevent hypertension during 7 years of follow-up. These results are possibly limited by non-study calcium use.107
A review of 4 randomized trials with 242 patients found vitamin D supplements decreased fasting glucose levels in patients with prediabetes and type 2 diabetes. Vitamin D was also associated with improved sensitivity to insulin in 6 trials with 316 patients. However, there were no significant differences in long-term glucose control in 4 trials with 184 patients or progression to diabetes in 2 trials.112
One preliminary study suggests that supplementation with vitamin D and calcium may be helpful for women with polycystic ovary syndrome.54
A meta-analysis (formal statistical review) of published studies found some evidence that use of vitamin D at recommended levels may reduce overall mortality.102 This article suggested, but did not attempt to establish, just how vitamin D might accomplish this. Similarly, an extensive 2011 review of 50 randomized trials (including 94,148 people) found that vitamin D 3 (but not other forms of the vitamin) reduced the risk of mortality among elderly women at risk for vitamin D deficiency.109
Vitamin D is sometimes mentioned as a treatment for psoriasis. However, this recommendation is based on Danish studies using calcipotriol, a variation of vitamin D 3 that is used externally (applied to the skin).55 Calcipotriol does not affect your body's absorption of calcium, so it is a very different substance from the vitamin D you can purchase at a store.
It has been suggested that since vitamin D levels in the body drop in the wintertime, vitamin D supplements might be helpful for seasonal affective disorder ("winter blues"). A small double-blind, placebo-controlled trial conducted during winter on 44 people found that vitamin D supplements produced improvements in various measures of mood.79 However, a double-blind, placebo-controlled study of 2,217 women over 70 failed to find benefit.91 It has been hypothesized that light therapy (used successfully for SAD) works by raising vitamin D levels, but there is some evidence that this is not the case.92
A randomized, placebo-controlled trial involving 164 men (aged 18-28) found that taking vitamin D 3 (400 units daily for 6 months) may prevent respiratory infections.110 But, there was no evidence that the vitamin decreased sick days or severity of cold symptoms.
Vitamin D supplements also do not appear to help enhance growth in healthy children.80
What Is the Scientific Evidence for Vitamin D? TOP
Individuals with severe osteoporosis often have low levels of vitamin D.56,58 Supplementing with vitamin D alone is probably no more than minimally helpful, at best,59,60,81,99,100 but the combination of calcium and vitamin D is probably more effective. (See the Calcium article for more information.)
Supplementation with vitamin D plus calcium may aid healing after a fracture has occurred.88
Interestingly, vitamin D may offer another benefit for osteoporosis in seniors: most (though not all) studies have found that vitamin D supplementation improves balance in seniors (especially female seniors) and reduces risk of falling.77,78,82,83,85-87,93-97,99,103,104 However, this was not the case in a randomized trial of 409 women who lived at home with a history of one or more falls in the past year. Vitamin D without exercise was not associated with a reduced risk of falls when compared to placebo combined with exercise. In this case, strength and balance exercises were the only interventions that improved physical functioning.115
In two reviews of 13 randomized trials with 4,394 patients, vitamin D 3 supplements (oral or intramuscular injection) were not effective in reducing depressive symptoms when compared to placebo. However, some benefit was found in an analysis of 2 trials with patients who had more severe, clinically significant depression.113,114
Safety Issues TOP
When taken at recommended dosages, vitamin D appears to be safe. However, when used at considerable excess, vitamin D can build up in the body and cause toxic symptoms. At an intake level of about 40,000 IU daily (about 100 times the recommended daily intake) vitamin D can cause dangerous elevations in blood calcium levels.101 Doses five times higher than this were consumed by a few individuals due to a manufacturing error; the resulting toxicity was severe and may have caused death in one individual.101
However, short of these vastly excessive dosages, it is not clear at what level vitamin D becomes toxic. The safe upper limits for vitamin D daily intake are as follows:108
Note, however, that some authorities believe these upper limits have been set a bit too low.66,68 Their arguments closely parallel those discussed in the Requirements/Sources section regarding nutritional needs.
There is no disagreement that people with sarcoidosis or hyperparathyroidism should never take vitamin D without first consulting a physician.
Taking vitamin D and calcium supplements might interfere with some of the effects of drugs in the calcium-channel blocker family.69 It is very important that you consult your physician before trying this combination.
The combination of calcium, vitamin D, and thiazide diuretics could potentially lead to excessive calcium levels in the body.70,72 If you are taking thiazide diuretics, you should consult with a physician about the right doses of vitamin D and calcium for you.
Interactions You Should Know About TOP
References[ + ]
1. Glerup H, Mikkelsen K, Poulsen L, et al. Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. J Intern Med. 2000;247:260-268.
2. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999;69:842-856.
3. Moon JC. A brief history of vitamin D toxicity. J Appl Nutr. 1997;49:18-31.
4. Shah M, Salhab N, Patterson D, et al. Nutritional rickets still afflict children in north Texas. Tex Med. 2000;96:64-68.
5. Utiger RD. The need for more vitamin D. N Engl J Med. 1998;338:828-829.
6. Werbach MR. Foundations of Nutritional Medicine: A Sourcebook of Clinical Research. Tarzana, Calif: Third Line Press; 1997:74-75.
7. Gloth FM 3rd, Tobin JD. Vitamin D deficiency in older people. J Am Geriatr Soc. 1995;43:822-828.
8. Fuller KE, Casparian JM. Vitamin D: balancing cutaneous and systematic considerations. South Med J. 2001;94:58-64.
9. Holmes RP, Kummerow FA. The relationship of adequate and excessive intake of vitamin D to health and disease. J Am Coll Nutr. 1983;2:173-199.
10. Roe DA. Drug-Induced Nutritional Deficiencies. 2nd ed. Westport, CT: AVI Publishing Company; 1985:164-166, 249.
11. Roe DA, Campbell TC, eds. Drugs and Nutrients: The Interactive Effects. New York, NY: M Dekker; 1984:505-523.
12. Hodges RE, Adelman RD. Nutrition in Medical Practice. Philadelphia, PA: Saunders; 1980:323-331.
13. Bengoa JM, Bolt MJ, Rosenberg IH. Hepatic vitamin D 25-hydroxylase inhibition by cimetidine and isoniazid. J Lab Clin Med. 1984;104:546-552.
14. Odes HS, Fraser GM, Krugliak P, et al. Effect of cimetidine on hepatic vitamin D metabolism in humans. Digestion. 1990; 46:61-64.
15. [No authors listed]. Cimetidine inhibits the hepatic hydroxylation of vitamin D. Nutr Rev. 1985;43:184-185.
16. Brodie MJ, Boobis AR, Hillyard CJ, et al. Effect of isoniazid on vitamin D metabolism and hepatic monooxygenase activity. Clin Pharmacol Ther. 1981;30:363-367.
17. Hahn TJ, Hendin BA, Scharp CR, et al. Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults. N Engl J Med. 1972;287:900-904.
18. Jubiz W, Haussler MR, McCain TA, et al. Plasma 1,25-dihydroxyvitamin D levels in patients receiving anticonvulsant drugs. J Clin Endocrinol Metab. 1977;44:617-621.
19. Williams C, Netzloff M, Folkerts L, et al. Vitamin D metabolism and anticonvulsant therapy: effect of sunshine on incidence of osteomalacia. South Med J. 1984;77:834-836, 842.
20. Tomita S, Ohnishi J, Nakano M, et al. The effects of anticonvulsant drugs on vitamin D3-activating cytochrome P-450-linked monooxygenase systems. J Steroid Biochem Mol Biol. 1991;39:479-485.
21. Buckley LM, Leib ES, Cartularo KS, et al. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-controlled study. Ann Intern Med. 1996;125:961-968.
22. Aarskog D, Aksnes L, Markestad T, et al. Heparin-induced inhibition of 1,25-dihydroxyvitamin D formation. Am J Obstet Gynecol. 1984;148:1141-1142.
23. Haram K, Hervig T, Thordarson H, et al. Osteopenia caused by heparin treatment in pregnancy. Acta Obstet Gynecol Scand. 1993;72:674-675.
24. Wise PH, Hall AJ. Heparin-induced osteopenia in pregnancy. Br Med J. 1980;281:110-111.
25. Brodie MJ, Boobis AR, Dollery CT, et al. Rifampicin and vitamin D metabolism. Clin Pharmacol Ther. 1980;27:810-814.
26. Williams SE, Wardman AG, Taylor GA, et al. Long term study of the effect of rifampicin and isoniazid on vitamin D metabolism. Tubercle. 1985;66:49-54.
27. Perry W, Erooga MA, Brown J, et al. Calcium metabolism during rifampicin and isoniazid therapy for tuberculosis. J R Soc Med. 1982;75:533-536.
28. Dawson-Hughes B, Harris SS, Krall EA, et al. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997;337:670-676.
29. Dawson-Hughes B, Dallal GE, Krall EA, et al. Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Ann Intern Med. 1991;115:505-512.
30. Garland FC, Garland CF, Gorham ED, et al. Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prev Med. 1990; 19:614-622.
31. Key SW, Marble M. Studies link sun exposure to protection against cancer. Cancer Weekly Plus. 1997 Nov 17:5-6.
32. Martinez ME, Giovannucci EL, Colditz GA, et al. Calcium, vitamin D, and the occurrence of colorectal cancer among women. J Natl Cancer Inst. 1996;88:1375-1382.
33. Kearney J, Giovannucci E, Rimm EB, et al. Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men. Am J Epidemiol. 1996;143:907-917.
34. James SY, Mackay AG, Colston KW. Effects of 1,25 dihydroxyvitamin D3 and its analogues on induction of apoptosis in breast cancer cells. J Steroid Biochem Mol Biol. 1996;58:395-401.
35. Taylor JA, Hirvonen A, Watson M, et al. Association of prostate cancer with vitamin D receptor gene polymorphism. Cancer Res. 1996;56:4108-4110.
36. Douglas WC. Vitamin D scores again. Second Opinion. 1997;7:4-5.
37. Fuller KE, Casparian JM. Vitamin D: balancing cutaneous and systematic considerations. South Med J. 2001;94:58-64.
38. Gilchrest BA, Eller MS, Geller AC, et al. The pathogenesis of melanoma induced by ultraviolet radiation. N Engl J Med. 1999;340:1341-1348.
39. Studzinski GP, Moore DC. Sunlight—can it prevent as well as cause cancer? Cancer Res. 1995;55:4014-4022.
40. Blutt SE, Weigel NL. Vitamin D and prostate cancer. Proc Soc Exp Biol Med. 1999;221:89-98.
41. Vandewalle B, Hornez L, Wattez N, et al. Vitamin-D3 derivatives and breast-tumor cell growth: effect on intracellular calcium and apoptosis. Int J Cancer. 1995;61:806-811.
42. Hofer H, Ho GM, Peterlik M, et al. Biological effects of 1alpha-hydroxy- and 1beta-(hydroxymethyl)-vitamin D compounds relevant for potential colorectal cancer therapy. J Pharmacol Exp Ther. 1999;291:450-455.
43. Tong WM, Kallay E, Hofer H, et al. Growth regulation of human colon cancer cells by epidermal growth factor and 1,25-dihydroxyvitamin D3 is mediated by mutual modulation of receptor expression. Eur J Cancer. 1998;34:2119-2125.
44. Ekman P. Genetic and environmental factors in prostate cancer genesis: identifying high-risk cohorts. Eur Urol. 1999;35:362-369.
45. Peehl DM. Vitamin D and prostate cancer risk. Eur Urol. 1999;35:392-394.
46. Hanchette CL, Schwartz GG. Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation. Cancer. 1992;70:2861-2869.
47. Moffatt KA, Johannes WU, Miller GJ. 1Alpha,25dihydroxyvitamin D3 and platinum drugs act synergistically to inhibit the growth of prostate cancer cell lines. Clin Cancer Res. 1999;5:695-703.
48. Danielsson C, Torma H, Vahlquist A, et al. Positive and negative interaction of 1,25-dihydroxyvitamin D3 and the retinoid CD437 in the induction of human melanoma cell apoptosis. Int J Cancer. 1999;81:467-470.
49. Evans SR, Houghton AM, Schumaker L, et al. Vitamin D receptor and growth inhibition by 1,25-dihydroxyvitamin D3 in human malignant melanoma cell lines. J Surg Res. 1996;61:127-133.
50. Rostand SG. Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension. 1997;30(2 pt 1):150-156.
51. Scragg R. Sunlight, vitamin D, and cardiovascular disease. In: Crass MF II, Avioli LV, eds. Calcium Regulating Hormones and Cardiovascular Function. Boca Raton, FL: CRC Press; 1995:213-237.
52. O'Connell TD, Simpson RU. 1,25-dihydroxyvitamin D3 and cardiac muscle structure and function. In: Crass MF II, Avioli LV, eds. Calcium-Regulating Hormones and Cardiovascular Function. Boca Raton, FL: CRC Press; 1995:191-211.
53. Fuller KE, Casparian JM. Vitamin D: balancing cutaneous and systematic considerations. South Med J. 2001;94:58-64.
54. Thys-Jacobs S, Donovan D, Papadopoulos A, et al. Vitamin D and calcium dysregulation in the polycystic ovarian syndrome. Steroids. 1999;64:430-435.
55. Kragballe K. Vitamin D3 analogues in psoriasis. Dermatologica. 1990;180:110-111.
56. LeBoff MS, Kohlmeier L, Hurwitz S, et al. Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA. 1999;281:1505-1511.
57. Mezquita-Raya P, Munoz-Torres M, De Dios Luna J, et al. Relation between vitamin D insufficiency, bone density, and bone metabolism in healthy postmenopausal women. J Bone Miner Res. 2001;16:1408-1415.
58. Sato Y, Asoh T, Kondo I, et al. Vitamin D deficiency and risk of hip fractures among disabled elderly stroke patients. Stroke. 2001;32:1673-1677.
59. Lips P, Graafmans WC, Ooms ME, et al. Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial. Ann Intern Med. 1996;124:400-406.
60. Hunter D, Major P, Arden N, et al. A randomized controlled trial of vitamin D supplementation on preventing postmenopausal bone loss and modifying bone metabolism using identical twin pairs. J Bone Miner Res. 2000;15:2276-2283.
61. Dawson-Hughes B, Harris SS, Krall EA, et al. Effect of withdrawal of calcium and vitamin D supplements on bone mass in elderly men and women. Am J Clin Nutr. 2000;72:745-750.
62. Dawson-Hughes B, Dallal GE, Krall EA, et al. Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Ann Intern Med. 1991;115:505-512.
63. Dawson-Hughes B, Harris SS, Krall EA, et al. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997;337:670-676.
64. Homik J, Suarez-Almazor ME, Shea B, et al. Calcium and vitamin D for corticosteroid-induced osteoporosis. Cochrane Database Syst Rev. 2000;2:CD000952.
65. Buckley LM, Leib ES, Cartularo KS, et al. Calcium and vitamin D 3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1996;125:961-968.
66. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999;69:842-856.
67. Moon JC. A brief history of vitamin D toxicity. J Appl Nutr. 1997;49:18-31.
68. Vieth R, Chan PC, MacFarlane GD. Efficacy and safety of vitamin D(3) intake exceeding the lowest observed adverse effect level. Am J Clin Nutr. 2001;73:288-294.
69. Bar-Or D, Gasiel Y. Calcium and calciferol antagonise effect of verapamil in atrial fibrillation. Br Med J (Clin Res Ed). 1981;282:1585-1586.
70. Riis B, Christiansen C. Actions of thiazide on vitamin D metabolism: a controlled therapeutic trial in normal women early in the postmenopause. Metabolism. 1985;34:421-424.
71. Lemann J, Gray RW, Maierhofer WJ, et al. Hydrochlorothiazide inhibits bone resorption in men despite experimentally elevated serum 1,25-dihydroxyvitamin D concentrations. Kidney Int. 198528:951-958.
72. Crowe M, Wollner L, Griffiths RA. Hypercalcaemia following vitamin D and thiazide therapy in the elderly. Practitioner. 1984;228:312-313.
74. Hypponen E, Laara E, Reunanen A, et al. Intake of vitamin D and risk of type I diabetes: a birth-cohort study. Lancet. 2001;358:1500-1503.
75. The EURODIAB Substudy 2 Study Group. Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. Diabetologia. 1999;42:51-54.
76. Stene LC, Ulriksen J, Magnus P, et al. Use of cod liver oil during pregnancy associated with lower risk of Type I diabetes in the offspring. Diabetologia. 2000;43:1093-1098.
77. Pfeifer M, Begerow B, Minne H, et al. Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res. 2000;15:1113-1118.
78. Janssen HC, Samson MM, Verhaar HJ. Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr. 2002;75:611-615.
79. Lansdowne AT, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl). 1998;135:319-323.
80. Schou AJ, Heuck C, Wolthers OD. A randomized, controlled lower leg growth study of vitamin D supplementation to healthy children during the winter season. Ann Hum Biol. 2003;30:214-219.
81. Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ. 2003;326:469.
82. Bischoff HA, Stahelin HB, Dick W, et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res. 2003;18:343-351.
83. Latham NK, Anderson CS, Lee A, et al. A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: the frailty interventions trial in elderly subjects (FITNESS). J Am Geriatr Soc. 2003;51:291-299.
84. Grau MV, Baron JA, Sandler RS, et al. Vitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial. J Natl Cancer Inst. 2003; 95:1765-1771.
85. Harwood RH, Sahota O, Gaynor K, et al. A randomised, controlled comparison of different calcium and vitamin D supplementation regimens in elderly women after hip fracture: The Nottingham Neck of Femur (NONOF) Study. Age Ageing. 2004;33:45-51.
86. Kenny AM, Biskup B, Robbins B, et al. Effects of vitamin D supplementation on strength, physical function, and health perception in older, community-dwelling men. J Am Geriatr Soc. 2003;51:1762-1767.
87. Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, et al. Effect of vitamin D on falls: a meta-analysis. JAMA. 2004;291:1999-2006.
88. Doetsch AM, Faber J, Lynnerup N, et al. The effect of calcium and vitamin D(3) supplementation on the healing of the proximal humerus fracture: a randomized placebo-controlled study. Calcif Tissue Int. 2004 May 27. [Epub ahead of print]
89. Duplessis CA, Harris EB, Watenpaugh DE, et al. Vitamin D supplementation in underway submariners. Aviat Space Environ Med. 2005;76:569-575.
90. Giovannucci E, Liu Y, Rimm EB, et al. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst. 2006;98:451-459.
91. Dumville JC, Miles JN, Porthouse J, et al. Can vitamin D supplementation prevent winter-time blues? A randomised trial among older women. J Nutr Health Aging. 2006;10:151-153.
92. Partonen T, Vakkuri O, Lamberg-Allardt C, Lonnqvist J. Effects of bright light on sleepiness, melatonin, and 25-hydroxyvitamin D(3) in winter seasonal affective disorder. Biol Psychiatry. 1996;39:865-872.
93. Bischoff-Ferrari HA, Conzelmann M, Stahelin HB, et al. Is fall prevention by vitamin D mediated by a change in postural or dynamic balance? Osteoporos Int. 2006 Mar 1. [Epub ahead of print]
94. Bischoff-Ferrari HA, Orav EJ, Dawson-Hughes B, et al. Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial. Arch Intern Med. 2006;166:424-430.
95. Sato Y, Iwamoto J, Kanoko T, et al. Low-Dose Vitamin D Prevents Muscular Atrophy and Reduces Falls and Hip Fractures in Women after Stroke: A Randomized Controlled Trial. Cerebrovasc Dis. 2005 Jul 27. [Epub ahead of print].
96. Law M, Withers H, Morris J, et al. Vitamin D supplementation and the prevention of fractures and falls: results of a randomised trial in elderly people in residential accommodation. Age Ageing. 2006 Apr 26. [Epub ahead of print]
97. Bunout D, Barrera G, Leiva L, et al. Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Exp Gerontol. 2006 Jun 21 [Epub ahead of print]
98. Hypponen E, Power C. Vitamin D Status and Glucose Homeostasis in the 1958 British Birth Cohort: The role of obesity. Diabetes Care. 2006;29:2244-2246.
99. Bischoff-Ferrari HA, Dawson-Hughes B. Where do we stand on vitamin D? Bone. 2007 Mar 24. [Epub ahead of print]
100. Lyons RA, Johansen A, Brophy S, et al. Preventing fractures among older people living in institutional care: a pragmatic randomised double blind placebo controlled trial of vitamin D supplementation. Osteoporos Int. 2007;18:811-818.
101. Klontz KC, Acheson DW. Dietary supplement induced vitamin D intoxication. N Engl J Med. 2007;357:308-309.
102. Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med. 2007;167:1730-1737.
103. Fosnight SM, Zafirau WJ, Hazelett SE. Vitamin d supplementation to prevent falls in the elderly: evidence and practical considerations. Pharmacotherapy. 2008;28:225-234.
104. Pfeifer M, Begerow B, Minne HW, et al. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int. 2008 Jul 16.
105. Wei MY, Garland CF, Gorham ED, et al. Vitamin D and prevention of colorectal adenoma: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2008;17:2958-2969.
106. Chlebowski RT, Johnson KC, Kooperberg C, et al. Calcium plus vitamin D supplementation and the risk of breast cancer. J Natl Cancer Inst. 2008;100:1581-1591.
107. Margolis KL, Ray RM, Van Horn L, et al. Effect of calcium and vitamin D supplementation on blood pressure: the Women's Health Initiative Randomized Trial. Hypertension. 2008 Nov;52(5):847-55.
109. Bjelakovic G, Gluud LL, Nikolova D, et al. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev. 2011;(7):CD007470.
110. Laaksi I, Ruohola JP, Mattila V, Auvinen A, Ylikomi T, Pihlajamäki H. Vitamin D supplementation for the prevention of acute respiratory tract infection: a randomized, double-blinded trial among young Finnish men. J Infect Dis. 2010;202(5):809-814.
111. Murad MH, Elamin KB, Abu Elnour NO, et al. Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011;96(10):2997-3006.
112. George PS, Pearson ER, Witham MD. Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis. Diabet Med. 201229(8):e142-e150.
113. Shaffer JA, Edmondson D, et al. Vitamin D supplementation for depressive symptoms: A systematic review and meta-analysis of randomized controlled trials. 2014;76(3):190-196.
114. Li G, Mbuagbaw L, et al. Efficacy of vitamin D supplementation in depression in adults: a systematic review. J Clin Endocrinol Metab. 2014;99(3):757-767.
115. Uusi-Rasi K, Patil R, Karinkanta S, et al. Exercise and vitamin D in fall prevention among older women: A randomized clinical trial. JAMA Intern Med. 2015;175(5):703-711.
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