Fine Needle Biopsy
by Patty Kellicker
A biopsy is a procedure to remove a tissue sample. In a fine needle biopsy (FNB), fluid and cells are removed with a thin, hollow needle.
Reasons for Procedure TOP
This biopsy is used to evaluate organ or tumor tissue. The sample may show abnormal cells, disease, infection, or inflammation.
FNB may also be done to find out how certain treatments are working.
Possible Complications TOP
Complications are rare, but no procedure is completely free of risk. The potential complications will depend on the location of the biopsy. Your doctor will review a list of possible complications, which may include:
Factors that may increase the risk of complications include:
What to Expect TOP
Prior to Procedure
Ask your doctor if there are any instructions you should follow before the procedure. Depending on the part of the body that the biopsy is being taken from, your doctor may ask you to:
Talk to your doctor about your medications. You may be asked to stop taking some medications up to one week before the procedure.
Just before the test, you may be asked to drink a contrast material. This drink will make images clearer on x-rays or CT scans.
Local anesthesia is often used. It will make the area numb. A sedative may also be used to help you relax.
Description of the Procedure TOP
You will be positioned for the easiest access to the area for biopsy. The area where the needle will be inserted will be cleaned. Anesthesia will be applied to numb the area. You will be asked to stay still. A thin, hollow needle will then be inserted through the skin to the site. The needle may need to be inserted more than once. The images may be checked to make sure the needle is in the right place. After the needle is in the proper position, tissue or fluid will be withdrawn. You may feel a pinch, pressure, or nothing at all. After the sample is obtained, the needle will be removed. The site will be bandaged.
How Long Will It Take? TOP
The length of procedure will depend on the site that is sampled:
Will It Hurt? TOP
The amount of discomfort you feel depends on the part of the body that is being examined. The anesthesia and sedative will prevent pain. You may feel a pinch or pressure. If you feel pain, tell the doctor right away.
After the procedure, the site will be tender. Talk to your doctor about medication to help manage discomfort.
Post-procedure Care TOP
The sample will be examined by a specialist. The results are usually ready in a few days. Your doctor will talk to you about the results.
Call Your Doctor TOP
Contact your doctor if your recovery is not progressing as expected or you develop complications, such as:
If you think you have an emergency, call for emergency medical services right away.
Family Doctor—American Academy of Family Physicians
National Cancer Institute
Biopsy for breast cancer diagnosis: Fine needle aspiration biopsy. University of California San Francisco Medical Center website. Available at: https://www.ucsfhealth.org/education/biopsy_for_breast_cancer_diagnosis/fine_needle_aspiration_biopsy/index.html. Accessed February 24, 2015.
Fine needle aspiration biopsy. American Academy of Otolaryngology—Head and Neck Surgery website. Available at:
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Accessed February 24, 2015.
Fine needle aspiration, fluid aspiration, and/or core biopsy. National Institute of Health Patient Education website. Available at:
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Updated July 2009. Accessed February 24, 2015.
6/3/2011 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com: Mills E, Eyawo O, Lockhart I, et al. Smoking cessation reduces postoperative complications: a systematic review and meta-analysis. Am J Med. 2011;124(2):144-154.
Last reviewed March 2016 by Mohei Abouzied, MD
Last Updated: 3/18/2013
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