Primary Ovarian Failure
(Primary Ovarian Insufficiency, Premature Menopause)
Pri-mary O-vair-e-un In-suff-e-shen-see
by Cynthia M. Johnson, MA
Primary ovarian failure (POF) is the reduction of ovarian function and/or stoppage of ovulation before menopause has started. Ovaries make certain hormones called estrogen and progesterone that affect many parts of the body. Loss or changes in these hormones can affect the health of the bones, heart, and blood vessels.
POF is caused by damage or destruction of the ovaries.
In most women, the cause is known. Other common reasons include:
Risk Factors TOP
Factors that may increase your chances of POF:
When symptoms develop, they may include:
You will be asked about your symptoms and medical history. A physical exam and a pelvic exam may also be done.
Tests may include:
The goal of treatment is to manage any problems caused by the change in hormones. You and your doctor can talk about the best treatment plan for you. Options include:
Women who are planning a procedure or treatment with a risk of POF may consider fertility preservation and family planning options before undergoing treatment. One option is to preserve healthy eggs to be used during IVF at a later date.
Women with POF may will also need to be followed for the development of other endocrine problems and heart disease.
Women with cancer should discuss treatment options with their doctors.
RESOLVE—The National Infertility Association
The American Congress of Obstetricians and Gynaecologists
The Society of Obstetricians and Gynecologists of Canada
Committee opinion no. 605: primary ovarian insufficiency in adolescents and young women. Obstet Gynecol. 2014;124(1):193-197. Reaffirmed 2016. Available at: https://www.acog.org/Clinical-Guidance-and-Publications/Committee-Opinions/Committee-on-Adolescent-Health-Care/Primary-Ovarian-Insufficiency-in-Adolescents-and-Young-Women.
Premature ovarian failure: Premature menopause. American Pregnancy Association website. Available at:
...(Click grey area to select URL)
Updated August 2015. Accessed December 20, 2017.
Premature ovarian insufficiency. Patient website. Available at: https://patient.info/health/menopause-hrt/premature-ovarian-insufficiency. Updated January 19, 2016. Accessed December 20, 2017.
Primary ovarian insufficiency (POI). EBSCO DynaMed Plus website. Available at: http://www.ebscohost.com/dynamed . Updated September 29, 2017. Accessed December 20, 2017.
Primary ovarian insufficiency (POI). National Institute of Child Health and Human Development website. Available at: https://www.nichd.nih.gov/health/topics/poi. Updated December 1, 2016. Accessed December 20, 2017.
Last reviewed November 2018 by EBSCO Medical Review Board Michael Woods, MD, FAAP
Last Last updated: 12/20/2017
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