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Diindolylmethane

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Introduction

Diindolylmethane is a compound found in cruciferous vegetables. These vegetables include broccoli, cabbage, kale, and brussels sprouts. The compound has been used to lower markers of cancer. It can be taken as a pill or by eating cruciferous vegetables.

Dosages

150 milligrams twice daily

What Research Shows

Not Enough Data to Assess

Cervical dysplasia1, 2

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take diindolylmethane for a short time. Not enough studies have been done to say whether it is safe to take for a long period.

Interactions

Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.

References►

1. Del Priore G, Gudipudi DK, et al. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol Oncol. 2010 Mar;116(3):464-467.

2. Castañon A, Tristram A, et al. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 2012 Jan 3;106(1):45-52.

Last reviewed February 2020 by EBSCO NAT Review Board Eric Hurwitz, DC
Last Updated: 5/27/2020

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