Drug Interactions: What You Need to Know
by
Jennifer Hellwig, MS, RD
Types of Drug InteractionsThere are 3 basic types of drug interactions: Drug-Drug InteractionsThese occur when one drug interferes with another drug, affecting how one or both act in or are eliminated from the body. These interactions can occur between prescription drugs, over-the-counter drugs, and even herbal or other dietary supplements, including vitamins. For example, vitamin E and aspirin both act to thin the blood. Taking these together could cause excessive bleeding. And combining antidepressants with the pain medication tramadol could cause seizures. It is particularly important to remember that herbal products, which many people regard as natural alternatives to drugs, still behave like drugs in the body. For example, the herb called St. John’s wort can reduce blood levels of certain medications. Furthermore, if a person is already taking St. John’s wort along with another drug, stopping the herb may cause drug levels to rise, potentially leading to dangerous complications. Drug-Food/Beverage InteractionsDrug-food/beverage interactions occur when a prescription or over-the-counter medication interacts with food or beverages. For example, taking the antibiotic tetracycline with a glass of milk can lessen the absorption of the antibiotic in the body and make it less effective. Grapefruit juice can block enzymes that metabolize numerous drugs, including some blood pressure-lowering drugs, anti-depressants, antihistamines, and the drug cyclosporine, thereby increasing blood levels of these drugs. Toxicity could result. Drug-Condition InteractionsThese occur when a prescription or over-the-counter medication interacts with a disease or condition. For example, decongestants, such as those found in many over-the-counter cold remedies, can cause an increase in blood pressure, which could be dangerous for people who already have high blood pressure. Symptoms of Drug InteractionsThe most common symptoms of drug interactions tend to be less serious and include the following:
More serious—but less common—symptoms and results of drug interactions include the following:
Consult your doctor or pharmacist if you experience any unusual side effect after taking a medication, no matter how mild or severe. How to Avoid Drug InteractionsThe key to avoiding drug interactions is to become informed about the potential interactions between all the drugs and dietary supplements you take by talking with your doctor and pharmacist. Some steps you can take include:
RESOURCES:United States Pharmacopeia (USP)
http://www.usp.org US Food & Drug Administration
https://www.fda.gov CANADIAN RESOURCES:Canadian Medical Association
https://www.cma.ca Health Canada
http://www.hc-sc.gc.ca References:
Drug interactions: what you should know. US Food & Drug Administration website. Available at:
https://www.fda.gov/drugs/resourcesforyou/ucm163354.htm. Updated
September 25, 2013. Accessed May 1, 2017.
Avoiding drug interactions. US Food & Drug Administration website. Available at:
https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm096386.htm.
Updated July 25, 2015. Accessed May 1, 2017.
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Neuvonen PJ. Interactions with the absorption of tetracyclines. Drugs. 1976;11(1):45-54.
Sansone R, Sansone L. Tramadol. Psychiatry. 2009;6(4):17-21.
St. John's wort. EBSCO Natural and Alternative Treatments website. Available at:
...(Click grey area to select URL) Updated December 15, 2015. Accessed May 1, 2017. Last reviewed
April 2017
by Michael Woods, MD, FAAP
Last Updated: 5/1/2017 |
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