Can We Prevent or Delay Schizophrenia?

Rerun image 15-year-old Caitlin was an excellent student with many friends when she entered the ninth grade. One year later, she suddenly became restless in school, stopped paying attention to her teachers, and eventually failed all of her subjects. At home, she appeared increasingly withdrawn and isolated, spending hours sleeping or watching television. The previously even-tempered adolescent became angry, anxious, and suspicious of those around her. She was occasionally seen talking to herself while making repetitive, odd hand motions. Several years later, hearing voices and insisting that the CIA was hatching an elaborate plot to murder her and her family, she was diagnosed with schizophrenia.

If Caitlin had received help at the first sign of trouble, could her descent into psychosis have been prevented or delayed?

Are There Early Warning Signs?

Schizophrenia is a brain disorder that changes the way a person views reality, responds to others, and experiences emotion. It is a condition that affects every aspect of a person's life, including family relations, friendships, education, and career. While schizophrenia can manifest in different ways, early signs that can indicate a problem include:

  • Not caring about personal hygiene
  • Seeing or hearing things that are not really there
  • Acting or speaking in an unusual way that does not make sense
  • Having disorganized thoughts
  • Having strange beliefs or magical thinking
  • Withdrawing from others
  • Not having any motivation
  • Feeling suspicious of others
  • Having dramatic changes in your sleep pattern

There are programs in the United States and in other countries that focus on treating these early warning signs in an effort to prevent psychotic symptoms from developing any further. The Portland Identification and Early Referral (PIER) Program in Maine is one example. PIER aims to help children, teens, and young adults who are at risk for serious mental health conditions such as schizophrenia. If your child is struggling, for instance, the mental health professionals would assess them and create a treatment plan. Treatment may include educating the family about mental health disorders, providing the child with support in school or on the job, and prescribing medication if needed.

Is Early Intervention Effective?

Researchers attempted to answer this question by analyzing 18 studies that included 1,808 people with early signs of psychosis. Unfortunately, most of the studies were small and not well designed, making it difficult to draw firm conclusions. But several interventions—treatment by a specialized clinical team, family therapy, and support for employment—did appear to improve some outcomes, like complying more with treatment and being more likely to have a job.

The idea of early intervention is not without its opponents. Clinicians worry that labeling people —especially children—as high risk or treating people at risk for mental illness might affect one's self-image. Also, drugs used to treat schizophrenia have many side effects, some of which may prove life-threatening and/or may continue even after medications are stopped. Since there is no perfect test for early schizophrenia, some people who would never have developed schizophrenia will be labeled and treated.

These concerns need to be weighed against the possibility that early intervention may be able to prevent or reduce the severe symptoms of schizophrenia. The fact remains that many people experience significant delays in treating newly developed psychosis. Some experts feel that early, aggressive diagnosis and early, aggressive treatment of psychosis may be helpful in reducing the long-term effects of schizophrenia, including delaying disease progression to psychosis.


National Alliance on Mental Illness
Mental Health America


Canadian Psychiatric Association
Children's Mental Health Ontario


First episode: psychosis. National Alliance of Mental Illness website. Available at:
...(Click grey area to select URL)
Published 2011. Accessed January 21, 2016.
Marshall M, Rathbone J. Early intervention for psychosis. Cochrane Database Syst Rev. 2011;(6):CD004718.
McGlashan T, Miller T, Woods S. Pre-onset detection and intervention research in schizophrenia psychoses: current estimates of benefit and risk. Schizophrenia Bulletin. 2001;27(4):563-570. Available at:
...(Click grey area to select URL)
Accessed January 21, 2016.
Schizophrenia. EBSCO DynaMed website. Available at:
...(Click grey area to select URL)
Updated October 23, 2015. Accessed January 21, 2016.
Schizophrenia: what you need to know. Mental Health America website. Available at:
...(Click grey area to select URL)
Accessed January 21, 2016.
4/29/2016 DynaMed's Systematic Literature Surveillance
...(Click grey area to select URL)
Stafford MR, Jackson H, Mayo-Wilson E, Morrison AP, Kendall T. Early interventions to prevent psychosis: systematic review and meta-analysis. BMJ. 2013;346:f185.
Last reviewed January 2016 by Michael Woods, MD
Last Updated: 4/29/2016

EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

To send comments or feedback to our Editorial Team regarding the content please email us at Our Health Library Support team will respond to your email request within 2 business days.