Guggul is a small tree that grows in Southern Asia. The roots make a yellow resin called guggulu that has been used to lower cholesterol and body mass. It can be taken as a pill, powder, or extract.


There are no advised doses for guggul.

What Research Shows

May Be Effective

May Not Be Effective

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It may be safe for most adults to take guggul for a short time. Some people taking guggul have allergic reactions, skin rash, and itching.C1, C2 Not enough studies have been done to say whether it is safe to take for a long period or during pregnancy or breastfeeding.


Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse, such as:C3, C4

  • People taking medicine to treat or prevent blood clots should talk to their doctors before taking guggul. It may increase the risk of bleeding.
  • People with high blood pressure should talk to their doctors before taking guggul. It may interact with their medicines.


A. High Cholesterol

A1. Szapary PO, Wolfe ML, et al. Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial. JAMA. 2003 Aug 13;290(6):765-772.

A2. Nohr LA, Rasmussen LB, et al. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther Med. 2009 Jan;17(1):16-22.

B. Metabolic Syndrome

B1. Patti AM, Al-Rasadi K, et al. Effect of a Natural Supplement Containing Curcuma Longa, Guggul, and Chlorogenic Acid in Patients With Metabolic Syndrome. Angiology. 2015 Oct;66(9):856-861.

C. Safety

C1. Kölönte A, Guillot B, et al. Allergic contact dermatitis to guggul extract contained in an anticellulite gel-cream. Contact Dermatitis. 2006 Apr;54(4):226-227.

C2. Salavert M, Amarger S, et al. Allergic contact dermatitis to guggul in a slimming cream. Contact Dermatitis. 2007 May;56(5):286-287.

C3. Hasani-Ranjbar S, Nayebi N, et al. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review. Curr Pharm Des. 2010;16(26):2935-2947.

C4. Yellapu RK, Mittal V, et al. Acute liver failure caused by 'fat burners' and dietary supplements: a case report and literature review. Can J Gastroenterol. 2011 Mar;25(3):157-160.

Last reviewed February 2020 by EBSCO NAT Review Board Eric Hurwitz, DC
Last Updated: 6/22/2020

EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

To send comments or feedback to our Editorial Team regarding the content please email us at Our Health Library Support team will respond to your email request within 2 business days.