(CHI; Neonatal Hyperinsulinism)
by Cynthia M. Johnson, MA
Congenital Hyperinsulinism (CHI) is a high level of insulin. The condition is present from birth. High insulin causes low levels of glucose in the blood. Glucose is important fuel for all organs in the body.
Each episode of CHI can cause low energy and general ill feeling. Repeated low levels can cause serious health issues and slow growth. It may also lead to brain damage, because the brain is very sensitive to glucose levels.
CHI is caused by a defect in certain genes. There are different types of CHI based on which gene is affected. The genes control how much insulin is released. Insulin should only be released to balance glucose levels in the blood. With CHI, insulin is released even when it is not needed.
The risk of CHI is higher if there is a family history of CHI.
Some symptoms of CHI in newborns may include:
Symptoms in children may include:
The doctor will ask about a child’s symptoms and past health. A physical exam will be done. Tests may include:
Early treatment is important. It can help to decrease the risk of complications.
Low glucose levels can cause damage to growing brains. If CHI is present, treatment will help to keep blood glucose at safe levels. Steps may include:
Some types of CHI may go away on its own. Further care will not be needed.
Other types of CHI may be severe or permanent. Surgery may be needed to help control these types. The pancreas will be removed. The pancreas makes insulin. For some, surgery may be a cure. For others, it should decrease episodes of low blood glucose.
There are no steps to prevent CHI.
Congenital Hyperinsulinism International
National Organization for Rare Disorders
Canadian Organization for Rare Disorders
Congenital hyperinsulinism. Congenital Hyperinsulinism International website. Available at:
...(Click grey area to select URL)
Accessed January 11, 2019.
Congenital hyperinsulinism. Genetics Home Reference website. Available at: https://ghr.nlm.nih.gov/condition/congenital-hyperinsulinism. Published January 8, 2019. Accessed January 11, 2019.
Congenital hyperinsulinism. National Organization for Rare Disorders website. Available at: https://rarediseases.org/rare-diseases/congenital-hyperinsulinism/#investigational-therapies. Published 2016. Accessed January 11, 2019.
Neonatal hypoglycemia. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/neonatal-hypoglycemia-22. Updated August 20, 2018. Accessed January 11, 2019.
Last reviewed September 2020 by EBSCO Medical Review Board Chelsea Skucek, MSN, BS, RNC-NIC
Last Updated: 12/29/2020
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
To send comments or feedback to our Editorial Team regarding the content please email us at email@example.com. Our Health Library Support team will respond to your email request within 2 business days.
All rights reserved.