(GBM; Brain Tumor; Malignant Astrocytoma)
by Michael Jubinville, MPH
Glioblastoma multiforme (GBM) is the most common glioma. Glioma is a type of brain tumor. This tumor starts in the glial cells. These cells help the brain work.
GBM can develop quickly. It can also come from other slower growing brain tumors. GBMs are mainly found in the middle part of the brain. But, it can also start in the the base of the brain or spinal cord.
Cancer is when cells in the body split without control or order. They go on to form a growth or tumor. The term cancer refers to harmful growths. These growths attack nearby tissues. They also spread to the brain or spinal cord. It's not clear what causes this. It’s likely a mix of genes and the environment.
Your chances of GBM are higher if you:
Symptoms depend on the tumor's size and where it is. GBM may cause:
The doctor will ask about your symptoms and health history. Your answers and a physical exam may point to GBM. You may also have
Imaging tests such as:
Surgery is often done to confirm a diagnosis. It’s done to remove as much of the tumor as possible. In most cases, the entire tumor can’t be taken out. Other methods to treat GBM:
GBM is very hard to treat and has a low survival rate. You and your family may be advised to find:
There is no way to prevent GBM since the cause is unknown.
American Brain Tumor Association
American Cancer Society
Brain Tumour Foundation of Canada
Canadian Cancer Society
Brain tumors. American Association of Neurological Surgeons. Available at:
...(Click grey area to select URL)
Accessed July 26, 2018.
General information about adult primary central nervous (CNS) tumors. National Cancer Institute website. Available at: https://www.cancer.gov/types/brain/hp/adult-brain-treatment-pdq. Updated January 31, 2018. Accessed July 25, 2018.
Glioblastoma. EBSCO DynaMed Plus website. Available at: https://www.dynamed.com/topics/dmp~AN~T116043/Glioblastoma . Updated July 2, 2018. Accessed July 26, 2018.
Overview of intracranial tumors. Merck Manual Professional Version website. Available at: https://www.merckmanuals.com/professional/neurologic-disorders/intracranial-and-spinal-tumors/overview-of-intracranial-tumors. Updated June 2018. Accessed July 26, 2018.
Last reviewed May 2018 by EBSCO Medical Review Board Mohei Abouzied, MD, FACP
Last Updated: 7/26/2018
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
To send comments or feedback to our Editorial Team regarding the content please email us at email@example.com. Our Health Library Support team will respond to your email request within 2 business days.