Óxido Nitroso

Vitamina B12 y Folato - Complementación Posiblemente Útil

El gas de óxido nitroso se usa principalmente como un anestésico local en la odontología, así como en ciertas fases de la cirugía de bypass cardíaco.

Complementación Posiblemente Útil

De vez en cuando, el óxido nitroso puede provocar deficiencia significativa de vitamina B 12, especialmente en personas que ya están al borde de la deficiencia de dicha vitamina (por ejemplo, los vegetarianos al 100%) o quienes con frecuencia están expuestos al gas, como los dentistas y anestesiólogos.1–4

El efecto sobre la B 12 también impacta al folato.5, 6, 7

Tomar suplementos de folato y B 12 de acuerdo a los niveles de U.S. Dietary Reference Intake (conocido anteriormente como la Recommended Dietary Allowance) debe prevenir el desarrollo de cualquier problema.


1. Ermens AA, Refsum H, Rupreht J, et al. Monitoring cobalamin inactivation during nitrous oxide anesthesia by determination of homocysteine and folate plasma and urine. Clin Pharmacol Ther 49: 385 - 393, 1991.

2. Flippo TS and Holder WD Jr. Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B 12 deficiency. Arch Surg 128: 1391 - 1395, 1993.

3. Amos RJ, Amess JAL, Hinds CJ, and Mollin DL. Incidence and pathogenesis of acute megaloblastic bone-marrow change in patients receiving intensive care. Lancet 2: 835 - 839, 1982.

4. Shils M, et al. (eds.). Modern nutrition in health and disease, 9th ed. Baltimore: Williams and Wilkins, 1999: 1635.

5. Nunn JF, Chanarin I, Tanner AG, and Owen ER. Megaloblastic bone marrow changes after repeated nitrous oxide anesthesia. Reversal with folic acid. Br J Anaesth 58: 1469 - 1470, 1986.

6. Amos RJ, Amess JA, Hinds CJ, and Mollin DL. Investigations into the effect of nitrous oxide anesthesia on folate metabolism in patient receiving intensive care. Chemioterapia 4: 393 - 399, 1985.

7. Koblin DD, Tomerson BW, Waldman FM, et al. Effect of nitrous oxide on folate and vitamin B 12 metabolism in patients. Anesth Analg 71: 610 - 617, 1990.

Ultima revisión septiembre 2014 por EBSCO CAM Review Board
Last Updated: 9/18/2014

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