Definition

Sepsis is a systemic inflammatory response to a severe infection. The inflammatory response triggers a rapid series of events, such as leaking blood vessels and impaired blood flow.

Severe sepsis is associated with a drop in blood pressure. Low blood pressure reduces the amount of oxygen and nutrients going to the body's organs. This drop causes damage to the body's major organs.

Septic shock occurs when adequate blood pressure cannot be restored despite treatment with IV fluids. Septic shock may lead to multiple organ failure and death.

Causes

Septic shock is caused by an infection that overwhelms the body. Sepsis can be triggered by many different kinds of infections including:

• Bacterial—most common
• Fungal infections
• Viral
• Parasitic

Toxins Can Spread Through the Bloodstream Copyright © Nucleus Medical Media, Inc.

Risk Factors

Septic shock is more common in infants and in people over 50 years old. Other factors that may increase your chances of septic shock include:

• Weakened immune system
• Absence of your spleen
• Cancer
• Low white blood cell counts
• Chronic diseases
• Previous surgery

Symptoms

Septic shock may cause:

• Fever, which may be followed by a drop in body temperature to below normal
• Warm, flushed skin
• Chills
• Rapid, pounding heartbeat
• Rapid breathing or trouble breathing
• Confusion
• Reduced alertness
• Irregular blood pressure
• Reduced urination
• Severe bleeding— disseminated intravascular coagulation

Diagnosis

Your doctor will ask about your symptoms and medical history. A physical exam will be done.

Tests may include the following:

• Blood tests to assess white blood cell counts and inflammatory markers that might indicate how serious the infection is, as well as oxygen levels and kidney function to assess damage to specific organs.
• Cultures to check for infectious organisms
• ECG to check for heart rhythm irregularities
• Imaging tests may be used to look for specific sources of infection, such as pneumonia

Treatment

Sepsis and septic shock require immediate care. Treatment includes the following:

Prevention

Most cases of septic shock cannot be prevented. Promptly treating bacterial and other infections may help.