Pyoderma Gangrenosum
by
Krisha McCoy, MS DefinitionA skin ulcer is an open sore in the skin. Pyoderma gangrenosum is an uncommon form of skin ulcers. It usually occurs on the lower legs, but can occur anywhere on the skin.
CausesPyoderma gangrenosum is thought to be caused by a problem with the immune system. The immune system finds and attacks foreign items in the body like viruses. Sometimes the immune system attacks the body's own tissue. In this case, the immune system attacks an area of the skin. Risk FactorsPyoderma gangrenosum is more likely to occur in people who have other underlying medical conditions such as: SymptomsThe main symptom of pyoderma gangrenosum is a painful skin ulcer. These ulcers may begin as small-irritated bumps from an injury. However, the ulcer can grow up to 7.9 in (inches) (20 cm [centimeters]). The ulcers often have purple edges that appear worn away. DiagnosisYour doctor will ask about your symptoms and medical history. A physical exam will be done. You may be referred to a skin specialist. Pyoderma gangrenosum is diagnosed by its appearance. Your doctor will also want to rule out other conditions that can cause skin ulcers. To look for other factors that could cause ulcers, your doctor may order:
TreatmentTalk with your doctor about the best treatment plan for you. Treatment options include: MedicationsMedications to treat pyoderma gangrenosum include:
You may need other medications to treat any underlying conditions Preventing New UlcersUlcers often begin at the site of injuries. Take precaution to prevent injuries when possible. Wear proper safety gear and avoid high impact or full contact activities. See your doctor as soon as you notice a possible ulcer. PreventionThere are no current guidelines to prevent pyoderma gangrenosum. RESOURCES:American Academy of Dermatology https://www.aad.org American Autoimmune Related Diseases Association http://www.aarda.org CANADIAN RESOURCES:Canadian Dermatology Association https://www.dermatology.ca Canadian Institute for Health Information https://www.cihi.ca References:Charles CA, Leon A, Banta MR, Kirsner RS. Etanercept for the treatment of refractory pyoderma gangrenosum: a brief series.
Int J Dermatol. 2007;46(10):1095-1099. Pyoderma gangrenosum. DermNet New Zealand website. Available at:
https://www.dermnetnz.org/topics/pyoderma-gangrenosum. Updated September 2015. Accessed December 20, 2017.
Pyoderma gangrenosum. EBSCO DynaMed Plus website. Available at:
http://www.dynamed...
. Updated November 21, 2016. Accessed December 20, 2017.
Reguiaï Z, Grange F. The role of anti-tumor necrosis factor-alpha therapy in Pyoderma gangrenosum associated with inflammatory bowel disease.
Am J Clin Dermatol. 2007;8(2):67-77. Last reviewed November 2018 by
EBSCO Medical Review Board
Marcin Chwistek, MD Last Updated: 12/20/2014 |
|
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation. This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition. To send comments or feedback to our Editorial Team regarding the content please email us at healthlibrarysupport@ebsco.com. Our Health Library Support team will respond to your email request within 2 business days. |