Mesoglycan is a compound found in the intestines and blood vessels. It is taken from pigs or cows and made into a supplement. It has been used to increase blood flow. Mesoglycan can be applied to the skin, taken as a pill or injected into the muscle or bloodstream by a healthcare provider.
100 milligrams once daily
What Research Shows
May Be Effective
Not Enough Data to Assess
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
It may be safe to take mesoglycan by mouth for a short time. Not enough studies have been done to say whether it is safe to take for a long period or by women who are pregnant or breastfeeding. The FDA has also issued a warning against using supplements that contain animal products.D1
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.
A. Diabetic Retinopathy
A1. Pacella E, Pacella F, et al. A pilot clinical study on the effectiveness of mesoglycan against diabetic retinopathy. Clin Ter. 2012;163(1):19-22.
B1. Viliani T, Scarselli M, et al. Pharmacological treatment of mechanical edema: a randomized controlled trial about the effects of mesoglycan. Eur J Phys Rehabil Med. 2009 Mar;45(1):21-29.
C. Intermittent Claudication
C1. Laurora G, Ambrosoli L, et al. Treatment of intermittent claudication with defibrotide or mesoglycan. A double blind study. Panminerva Med. 1994 Jun;36(2):83-86.
C2. Nenci GG, Gresele P, et al. Treatment of intermittent claudication with mesoglycan—a placebo-controlled, double-blind study. Thromb Haemost. 2001 Nov;86(5):1181-1187.
D1. Important alert 17-04. Federal Drug Administration website. Available at: https://www.accessdata.fda.gov/cms_ia/importalert_53.html. Accessed May 29, 2019.
E. Venous Ulcers
E1. Arosio E, Ferrari G, et al. A placebo-controlled, double-blind study of mesoglycan in the treatment of chronic venous ulcers. Eur J Vasc Endovasc Surg. 2001 Oct;22(4):365-372.
Last reviewed March 2020 by EBSCO NAT Review Board Eric Hurwitz, DC
Last Updated: 6/29/2020
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
To send comments or feedback to our Editorial Team regarding the content please email us at firstname.lastname@example.org. Our Health Library Support team will respond to your email request within 2 business days.