Restless Legs Syndrome
Restless legs syndrome (RLS) is a nerve problem. It is an urge to move your legs that you cannot control. It is worse at night.
It can be managed with healthy habits and medicine. Natural treatments have been used to further ease symptoms. They should not be used instead of standard care.
Iron is an essential nutrient that is vital for blood flow. It is likely to help ease restless legs. ( Note : People with heart problems should not take iron. It may also cause constipation.)B2, B5, B7
May Be Effective
These supplements may help ease restless legs:
Other therapies that may help are:
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Herbs and Supplements to Be Used With Caution
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse, such as:
A1. Cui Y, Wang Y, et al. Acupuncture for restless legs syndrome. Cochrane Database Syst Rev. 2008;(4):CD006457.
A2. Raissi GR, Forogh B, et al. Evaluation of Acupuncture in the Treatment of Restless Legs Syndrome: A Randomized Controlled Trial. J Acupunct Meridian Stud. 2017 Oct;10(5):346-350.
A3. Xu XM, Liu Y, et al. Complementary and alternative therapies for restless legs syndrome: An evidence-based systematic review. Sleep Med Rev. 2018 Apr;38:158-167.
Herbs and Supplements
B1. Sagheb MM, Dormanesh B, et al. Efficacy of vitamins C, E and their combination for treatment of restless legs syndrome in hemodialysis patients: a randomized, double-blind, placebo-controlled trial. Sleep Med. 2012;13(5):542-545.
B2. Trotti LM, Becker LA. Iron for the treatment of restless legs syndrome. Cochrane Database Syst Rev. 2019;1:CD007843.
B3. Kwon S, Jin C, et al. Paeoniae Radix-containing herbal medicine for patients with restless legs syndrome: A systematic review and meta-analysis. Complement Ther Clin Pract. 2019 May;35:329-341.
B4. Xu XM, Liu Y, et al. Complementary and alternative therapies for restless legs syndrome: An evidence-based systematic review. Sleep Med Rev. 2018 Apr;38:158-167.
B5. Aurora RN, Kristo DA, et al. The treatment of restless legs syndrome and periodic limb movement disorder in adults--an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline. Sleep. 2012 Aug 1;35(8):1039-1062.
B6. Cuellar NG, Ratcliffe SJ. Does valerian improve sleepiness and symptom severity in people with restless legs syndrome? Altern Ther Health Med. 2009 Mar-Apr;15(2):22-28.
B7. Wang J, O'Reilly B, et al. Efficacy of oral iron in patients with restless legs syndrome and a low-normal ferritin: A randomized, double-blind, placebo-controlled study. Sleep Med. 2009 Oct;10(9):973-975.
Near-Infrared Light Therapy
C1. Mohammadi MM, Raygani AAV, et al. Effect of Near-Infrared Light Therapy Based on Acupoints on the Severity of Restless Legs Syndrome in Patients Undergoing Hemodialysis: A Single-Blind, Randomized Controlled Trial. Clin Med Res. 2018;16(1-2):1-8.
C2. Xu XM, Liu Y, et al. Complementary and alternative therapies for restless legs syndrome: An evidence-based systematic review. Sleep Med Rev. 2018 Apr;38:158-167.
D1. Xu XM, Liu Y, et al. Complementary and alternative therapies for restless legs syndrome: An evidence-based systematic review. Sleep Med Rev. 2018 Apr;38:158-167.
D2. Gopaluni S, Sherif M, et al. Interventions for chronic kidney disease-associated restless legs syndrome. Cochrane Database Syst Rev. 2016 Nov 7;11:CD010690.
Last reviewed November 2019 by EBSCO NAT Review Board Eric Hurwitz, DC
Last Updated: 6/15/2020
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