Persistent Pulmonary Hypertension of the Newborn
(PPHN; Persistent Fetal Circulation [PFC]; Syndrome of Pulmonary Hypertension of Newborn [SPHN])
by Cynthia M. Johnson, MA
Oxygen passes from a mother to a baby through the umbilical cord before birth. A baby's lungs should take over after birth. Persistent pulmonary hypertension of the newborn (PPHN) is when this does not happen and blood flows away from the lungs because of high blood pressure in the arteries that go to the lungs. The baby will not get enough oxygen. This is a serious problem that can cause long-term health problems.
The exact cause is not always known. It may be caused by
This problem is more common in full-term babies. It is also more common in premature babies who have health problems that affect breathing. Other things that may raise a baby's risk are:
PPHN may cause:
A physical exam will be done. Blood tests will also be done. The baby's oxygen levels will be checked. This can be done with pulse oximetry monitoring. This is often enough to make the diagnosis.
Images will be taken of the heart to confirm the diagnosis. This can be done with an echocardiogram.
The goal of treatment is to increase oxygen to the baby. This can be done with:
Other methods may be:
Medicine may be given to relax blood vessels and improve blood flow.
Extracorporeal Membrane Oxygenation (ECMO)
ECMO is a machine that can take over the job of the lungs. It requires major surgery. It may be done in babies with severe PPHN who do not respond to other treatments.
There are no known ways to prevent PPHN.
Healthy Children—American Academy of Pediatrics
Kids Health—Nemours Foundation
Nair J, Lakshminrusimha S. Update on PPHN: mechanisms and treatment. Semin Perinatol. 2014 Mar;38(2):78-91.
Persistent pulmonary hypertension of the newborn (PPHN). EBSCO DynaMed website. Available at: https://www.dyname.... Updated January 23, 2019. Accessed January 3, 2020.
Last reviewed September 2019 by EBSCO Medical Review Board Kari Kassir, MD
Last Updated: 7/17/2020
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
To send comments or feedback to our Editorial Team regarding the content please email us at firstname.lastname@example.org. Our Health Library Support team will respond to your email request within 2 business days.