Scleroderma is a rare problem with the immune system that causes a thickening of the skin, joints, and some organs.
There is no cure. It is managed with medicine and therapy. Some people may need surgery.
May Be Effective
Not Enough Data to Assess
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Herbs and Supplements to Be Used With Caution
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.
A1. Zhou J, Yang D, et al. Clinical Efficacy and Safety of Bathing with Chinese Medicine Taohong Siwu Decoction () for Treatment of Diffuse Cutaneous Systemic Sclerosis: A Randomized Placebo-Controlled Trial. Chin J Integr Med. 2018 Mar;24(3):185-192.
B1. Willems LM, Vriezekolk JE, et al. Effectiveness of Nonpharmacologic Interventions in Systemic Sclerosis: A Systematic Review. Arthritis Care Res (Hoboken). 2015 Oct;67(10):1426-1439.
B2. Moran ME. Scleroderma and evidence based non-pharmaceutical treatment modalities for digital ulcers: a systematic review. J Wound Care. 2014 Oct;23(10):510-516.
B3. Maddali-Bongi S, Landi G, et al. The rehabilitation of facial involvement in systemic sclerosis: efficacy of the combination of connective tissue massage, Kabat's technique and kinesitherapy: a randomized controlled trial. Rheumatol Int. 2011 Jul;31(7):895-901.
B4. Maddali Bongi S, Del Rosso A, et al. Efficacy of a tailored rehabilitation program for systemic sclerosis. Clin Exp Rheumatol. 2009 May-Jun;27(3 Suppl 54):44-50.
Manual Lymph Drainage
C1. Bongi SM, Del Rosso A, et al. Manual lymph drainage improving upper extremity edema and hand function in patients with systemic sclerosis in edematous phase. Arthritis Care Res (Hoboken). 2011 Aug;63(8):1134-1141.
Last reviewed November 2019 by EBSCO NAT Review Board Eric Hurwitz, DC
Last Updated: 6/17/2020
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
To send comments or feedback to our Editorial Team regarding the content please email us at email@example.com. Our Health Library Support team will respond to your email request within 2 business days.