Gastrointestinal Stromal Tumor
(GIST; Gastrointestinal Stromal Sarcoma; Gastric Myosarcoma; Gastric Myoblastoma; Gastrointestinal Leiomyosarcoma; Gastrointestinal Smooth Muscle Tumor)
by Cynthia M. Johnson, MA
A gastrointestinal stromal tumor (GIST) is a rare cancer in the digestive system. It often happens in the stomach.
The cause is not well understood. Many people with a GIST have a defect in a certain gene. The gene is active when it should not be. This allows cells to grow and divide without order. This may explain why a GIST forms.
This problem is more common in people who are over 50 years of age. Other things that may raise the risk are:
Problems may be:
The doctor will ask about your symptoms and health history. This may be enough to suspect the diagnosis.
Images may be taken. This can be done with:
A sample of the tumor will be taken to confirm the diagnosis. This can be done with a fine-needle biopsy.
Genetic tests may also be done. This can be done with blood tests.
Treatment will depend on the size of the tumor and whether it has spread. Options are:
There are no known methods to prevent this health problem.
American Cancer Society
American College of Gastroenterology
Canadian Association of Gastroenterology
Canadian Cancer Society
Gastrointestinal stromal tumor (GIST). EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/gastrointestinal-stromal-tumor-gist. Accessed August 16, 2021.
What are gastrointestinal stromal tumors? American Cancer Society website. Available at: https://www.cancer.org/cancer/gastrointestinal-stromal-tumor/about/what-is-gist.html. Accessed August 16, 2021.
Last reviewed July 2021 by EBSCO Medical Review Board James Cornell, MD
Last Updated: 8/16/2021
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
To send comments or feedback to our Editorial Team regarding the content please email us at firstname.lastname@example.org. Our Health Library Support team will respond to your email request within 2 business days.