by Amy Scholten, MPH
Hypercalcemia is when there is too much calcium in the blood. Calcium is a mineral needed for healthy bones, muscles, and nerves.
If left untreated, this condition can lead to kidney stones and other problems.
Hypercalcemia is caused by problems in how the body absorbs, balances, or keeps calcium.
Many conditions interfere with calcium balance. They cause extra calcium to be released into the blood. The most common cause of high calcium in the blood is an overactive parathyroid gland.
Low body fluids can cause short term high calcium levels.
Things that raise the risk of hypercalcemia are:
Symptoms of hypercalcemia may be:
The doctor will ask about symptoms and past health. A physical exam will be done.
Tests will be done to diagnose the condition and look for causes. They include:
If calcium levels are due to cancer or parathyroid problems, imaging may be done with:
Other tests may be done to check the effects of high calcium. Tests may be:
The goal is to bring calcium levels back to normal. Underlying causes also need to be treated. Treatment depends on the cause and severity of hypercalcemia. If the condition is severe, hospital care is needed.
Treatment may include drinking more fluids. For severe symptoms, IV fluids are needed.
If medicines are causing a problem, they may need to be stopped or changed.
Medicines may be given to control the condition causing the problem. They may also be given to remove calcium from the blood. Options may be:
Other treatments depend on the cause of hypercalcemia. They may include:
The outcome of treatment depends on the underlying cause.
The risk of hypercalcemia may be reduced by:
Family Doctor—American Academy of Family Physicians
The American Association of Clinical Endocrinologists
The Canadian Society of Endocrinology and Metabolism
Hypercalcemia. Children's Hospital of Philadelphia website. Available at: https://www.chop.edu/conditions-diseases/hypercalcemia. Accessed July 30, 2021.
Hypercalcemia. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/hypercalcemia . Accessed July 30, 2021.
Hypercalcemia Merck Manual Professional Version website. Aavailable at: https://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/electrolyte-disorders/hypercalcemia. Accessed July 30, 2021
Žofková I. Hypercalcemia. Pathophysiological aspects. Physiol Res. 2016;65(1):1-10.
Last reviewed July 2021 by EBSCO Medical Review Board Dan Ostrovsky, MD
Last Updated: 7/30/2021
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
To send comments or feedback to our Editorial Team regarding the content please email us at firstname.lastname@example.org. Our Health Library Support team will respond to your email request within 2 business days.
All rights reserved.