by Cynthia M. Johnson, MA
Neutropenic fever is a temperature over 100.4°F (38°C) in a person with neutropenia. Neutropenia is a low number of neutrophils in the blood. This is a type of white blood cell that helps the body fight infections.
The fever is caused by an infection.
Neutropenia can have many causes, such as cancer treatments. Other medicines, infections, or cancer itself may also be the cause.
Having neutropenia raises the risk of infection and fever. It is also more common in older adults.
Other things that raise the risk of this health problem are:
The main sign is a fever. There may also be chills and sweating.
You will be asked about your symptoms and health history. An exam will be done.
Your blood may be tested.
You may have more tests to look for the site of the infection.
An infection with neutropenia can be serious. Antibiotics will be given right away to treat infection.
Tests to find the cause of the infection can take a few days.
Some people with this health problem are at high risk for infection. Antibiotics may be given to help stop one before it happens.
Other steps to lower the risk of infections are:
American Cancer Society
National Heart, Lung, and Blood Institute
Canadian Cancer Society
Public Health Agency of Canada
Febrile neutropenia. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/febrile-neutropenia. Updated October 4, 2019. Accessed December 11, 2019.
Infections in people with cancer. American Cancer Society website. Available at:
...(Click grey area to select URL)
Accessed December 11, 2019.
Taplitz RA, Kennedy EB, et al. Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update. J Clin Oncol. 2018 May 10;36(14):1443-1453.
Last reviewed September 2019 by EBSCO Medical Review Board James Cornell, MD
Last Updated: 12/11/2019
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
To send comments or feedback to our Editorial Team regarding the content please email us at firstname.lastname@example.org. Our Health Library Support team will respond to your email request within 2 business days.