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Kawasaki Disease

  • Cynthia M. Johnson, MA
Publication Type:


Kawasaki Disease

(Kawasaki Syndrome; Mucocutaneous Lymph Node Syndrome)


Kawasaki disease is sudden inflammation of the blood vessels in young children.

This problem can lead to coronary artery disease. Care is needed right away. Early treatment can improve outcomes.

Coronary Arteries.

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The exact cause is not known. It is thought to be triggered by infection. The disease does not spread from person to person.

Risk Factors

This problem is more common in children who are Asian and Black. It is also more common in children who are younger than 5 years of age.

Outbreaks of the disease are more common in the winter and spring months.


A child may have these problems during the first two weeks of the disease:

  • A fever higher than 102 degrees Fahrenheit (38.8 degrees Celsius) that lasts at least five days
  • Whites of the eyes that are red or bloodshot
  • A reddish skin rash
  • Soreness and swelling of the mouth, lips, and throat
  • A white or yellow coating and bright red bumps on the tongue
  • Swollen hands and feet that may look red
  • Swollen glands in the neck
  • Irritability

Later problems may be:

  • Peeling of the skin on the hands and feet
  • Joint pain
  • Belly pain
  • Diarrhea
  • Vomiting


There is no test to diagnose Kawasaki disease. The doctor will ask about your child’s symptoms and health history. A physical exam will be done. This is often enough to make the diagnosis.

Blood and urine tests may be done to rule out other problems.

Images may be taken of your child's heart. This can be done with an echocardiogram .

The electrical activity of your child's heart may be measured. This can be done with an electrocardiogram (EKG) .


Kawasaki disease will go away on its own. Treatment can help limit damage. Medicine will be given, such as:

  • IV gamma globulin to fight infection
  • High doses of aspirin to ease swelling and fever
  • Steroids to ease inflammation that cannot be controlled with other medicines

Children with severe heart complications will need to have them treated as well.


There is no known way to prevent Kawasaki disease.





  • Kawasaki disease. American Heart Association website. Available at: https://www.heart.org/en/health-topics/kawasaki-disease.
  • Kawasaki disease. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/kawasaki-disease.
  • Kawasaki disease. Kids Health—Nemours Foundation website. Available at: https://www.kidshealth.org/en/parents/kawasaki.html.
  • Kawasaki disease in children. Cincinnati Children's Hospital website. Available at: http://www.cincinnatichildrens.org/health/k/kawasaki.
  • McCrindle BW, Rowley AH, et al. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation. 2017 Apr 25;135(17):e927-e999.


  • Kari Kuenn, MD
Last Updated:

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.