Acute Interstitial Nephritis
Acute interstitial nephritis (AIN) happens when the small tubes inside the kidneys become inflamed. This makes it hard for the kidneys to filter waste and extra fluid from the body.
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AIN may be caused by:
AIN is more common in older adults. Other things that may raise the risk are:
- Taking certain medicines
- Having an infection
Problems may be:
- Passing less urine (pee) than usual
- Lack of hunger
- Nausea and vomiting
- Pain in the side
- Joint pain
- Low fever
- Blood in the urine (rare)
The doctor will ask about symptoms and health history. A physical exam will be done. Blood and urine tests will be done to check kidney function.
A sample of tissue from the kidney may be taken and tested. This can be done with a biopsy.
The goal of treatment is to ease inflammation and improve kidney function. How this is done will depend on the cause.
Any medicines causing AIN will be stopped or changed. Other medicines may also be given, such as:
- Antibiotics to treat infection
- Pain relievers
- Corticosteroids to ease inflammation
People who are not helped by these methods may need dialysis. This is a machine that takes over the work of the kidneys by filtering blood.
This risk of AIN may be lowered by avoiding medicines that may harm the kidneys. They should only be taken when advised by a doctor.
- Acute interstitial nephritis. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/acute-interstitial-nephritis.
- Tubulointerstitial nephritis. Merck Manual Professional Version website. Available at: https://www.merckmanuals.com/professional/genitourinary-disorders/tubulointerstitial-diseases/tubulointerstitial-nephritis.
- Mark S. Itzkowitz, MD, JD
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