Chronic Kidney Disease
Condition
(CKD; Chronic Renal Disease)
Definition
Chronic kidney disease (CKD) is when the kidneys do not filter blood the right way. It happens over a long period of time. This causes waste to build up in the body and leads to other health problems.
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Causes
CKD is caused by damage or disease in the kidneys. Common causes are:
- Diabetes
- High blood pressure
- Problems with the kidneys, such as:
- Cystic kidney disease
- Blockages from kidney stones
- Glomerulonephritis
- Acute tubular necrosis
- Renal tubular disorders
- Damage due to drugs or toxins
- Severe infection
- Problems with the immune system
Risk Factors
CKD is more common in older adults. Smoking and alcohol use disorder are the main risk factors. Other things that may raise the risk are:
- Family history of kidney disease
- Diabetes
- High blood pressure
- Vesicoureteral reflux—back up of urine into kidneys
- Infections, such as long-term urinary tract infections
- Exposure to high levels of lead
- Being overweight or obese
- A prior kidney transplant
Symptoms
CKD may cause problems such as:
- Feeling tired or weak
- Trouble sleeping
- Not wanting to eat
- Nausea
- Itching
- Feeling that it is hard to breathe
- Change in how food tastes
- Feeling confused, restless, or sad
Diagnosis
The doctor will ask about symptoms and past health. A physical exam may be done. Blood and urine tests will be done to see how well the kidneys are working.
Other tests will be done to find a cause.
Treatment
There is no cure, but steps can be taken to prevent or slow damage and manage symptoms. Options are:
Prevention
To lower the risk of CKD:
- Manage health problems that can cause kidney damage, such as high blood pressure and diabetes
- Maintain a healthy weight through diet and exercise
- Do not smoke
- Limit alcohol
National Institute of Diabetes and Digestive and Kidney Diseases
National Kidney Foundation
CANADIAN RESOURCES:
Health Canada
The Kidney Foundation of Canada
National Institute of Diabetes and Digestive and Kidney Diseases
National Kidney Foundation
CANADIAN RESOURCES:
Health Canada
The Kidney Foundation of Canada
References
- Chronic kidney disease. National Institute of Diabetes and Digestive and Kidney Diseases. Available at: https://www.niddk.nih.gov/health-information/kidney-disease/chronic-kidney-disease-ckd.
- Chronic kidney disease (CKD) in adults. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/overview-of-chronic-kidney-disease-ckd-in-adults.
- Gaitonde DY, Cook DL, Rivera IM. Chronic kidney disease: detection and evaluation. Am Fam Physician. 2017;96(12):776-783.
Contributors
- Mark S. Itzkowitz, MD, JD
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