Neuropathic Pain
Condition
(Pain, Neuropathic; Nerve Pain; Pain, Nerve)
Definition
Neuropathic pain is a result of damage or disease of the peripheral nervous system.
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Causes
In some people, the cause of nerve pain is not known. In others, it may be caused by things like:
- Trauma
- Chemicals
- The nerve not getting the nutrients needed to work
- Infection, such as HIV
- The body's immune system attacking the nerves
Risk Factors
Health problems that may raise the risk are:
- Diabetes
- Poor glucose tolerance
- Shingles
- HIV infection
- Amputation
- Alcohol use disorder
- Lack of vitamins
- Spinal cord problem or injury
- Cancer
- Carpal tunnel syndrome
- Health problems that are present at birth
- Thyroid disorders
- Multiple myeloma
Other things that may raise the risk are:
- Back surgery
- Chemotherapy
- Being around toxins or metals
- Taking certain medicines
Symptoms
The pain may be all the time or may come and go during the day. Some problems may be:
- Burning
- Stabbing
- Electrical shock
- A feeling of pins and needles
- Numbness
Diagnosis
The doctor will ask about symptoms and health history. You will also be asked what the pain is like and when it happens. A physical exam will be done. You may be sent to a doctor who treats the nervous system.
Tests that may be done are:
- Blood tests to look for problems that may be causing the pain, such as a lack of certain vitamins and minerals
- Nerve conduction tests to find out how well nerves are passing electrical signals
- Electromyography (EMG) to measure the electrical activity in the nerves
- A tissue biopsy to look for problems that may be causing pain
Treatment
Any underlying problems will need to be treated, such as diabetes.
The goal of treatment is to manage symptoms. Options are:
Prevention
The risk of neuropathic pain may be lowered by managing other health problems, such as diabetes.
Medicine
One or more of these medicines may be given to manage pain:
- Over the counter or prescription pain relievers
- Antiseizure medicine
- Antidepressants
- Topical creams put on the skin or patches, such as capsaicin cream
Some states allow residents to use medical marijuana for health problems. It may be helpful for people with neuropathic pain related to HIV.
Medicine
One or more of these medicines may be given to manage pain:
- Over the counter or prescription pain relievers
- Antiseizure medicine
- Antidepressants
- Topical creams put on the skin or patches, such as capsaicin cream
Some states allow residents to use medical marijuana for health problems. It may be helpful for people with neuropathic pain related to HIV.
Procedures
Nerve decompression surgery may be advised to ease pain. Other procedures that may be done are:
- A nerve block—An anesthetic is injected into the painful site to block pain.
- Pain pump—A pain pump is placed in the body to deliver pain medicine.
- Nerve stimulators—A device is attached to the nerve to deliver electrical signals to control pain.
- Surgery may be done to block the hurt nerves from sending signals.
American Chronic Pain Association
National Institute of Neurological Disorders and Stroke
CANADIAN RESOURCES:
Canadian Diabetes Association
Chronic Pain Association of Canada
American Chronic Pain Association
National Institute of Neurological Disorders and Stroke
CANADIAN RESOURCES:
Canadian Diabetes Association
Chronic Pain Association of Canada
References
- Barrell K, Smith AG. Peripheral Neuropathy. Med Clin North Am. 2019 Mar;103(2):383-397.
- Causes. The Foundation for Peripheral Neuropathy website. Available at: https://www.foundationforpn.org/causes.
- Peripheral neuropathy. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/peripheral-neuropathy.
Contributors
- Mark S. Itzkowitz, MD, JD
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