Mitral Regurgitation
Condition
(Mitral Insufficiency)
Definition
The mitral valve sits in the left side of the heart. It helps control the flow of blood from the top part of the heart to the bottom part. The valve makes sure the blood moves in one direction.
Mitral regurgitation is a leak in this valve. Blood leaks back into the upper chamber. Minor leaks may not be noticed. Severe leaks can cause serious symptoms and illness. The sooner it is treated, the better the outcome.
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Causes
Mitral regurgitation may be the result of a valve problem such as:
- Mitral valve prolapse—the valve cannot close properly
- Several types of heart problems that a person is born with can affect how the mitral valve works.
The valve can also be harmed by other health issues such as:
- Infections that scar the heart valve such as rheumatic fever or bacterial endocarditis
- Heart attack
- Cardiomyopathies—weakens the heart muscle and stretches the mitral valve
Risk Factors
Things that may raise the chance of developing mitral regurgitation include:
- A history of rheumatic fever or other serious infectious disease
- Autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis
- Storage diseases such as hemochromatosis and glycogen storage disease
- Heart disease
- Muscle disease
- Malnutrition
- Alcohol use disorder
- Radiation exposure
- Exposure to certain drugs such as lithium, sulfonamides, chemotherapy, and phenothiazines
Symptoms
Symptoms may appear quickly or slowly over time. Mitral regurgitation can cause:
- A feeling of being tired that does not go away and gets worse over time
- Shortness of breath, especially with activity
- Shortness of breath that gets worse when lying down
- Feeling of fluttering in chest or racing heart rate
Diagnosis
The doctor will ask about symptoms and health history. A physical exam will be done. A leaking heart valve will make a sound called a murmur. The doctor may be able to hear it during an exam. A doctor who focuses on treating the heart may need to be seen.
Images of the heart will help find which valve is leaking. These may be taken with:
Treatment
- How bad the leak is
- How well the heart is working with the leak
Treatment options include:
Prevention
To help reduce the chances mitral regurgitation:
- Follow heart healthy habits such as:
- Control weight and blood pressure
- Work out regularly
- Eat heart-healthy foods
- Get health care right away for any infections
- Avoid IV drug use
- Limit alcohol intake
Medical Management
When possible the underlying cause will be treated. This may help the valve work normally again.
Medicine may help decrease symptoms and effects on the heart. It is an option for those who have a less severe form of the regurgitation that is slowly getting worse.
Medicine may also help steady severe disease for a short time. It may be used to help the heart before surgery. A pump may also be needed to help the heart be ready for surgery.
Medical Management
When possible the underlying cause will be treated. This may help the valve work normally again.
Medicine may help decrease symptoms and effects on the heart. It is an option for those who have a less severe form of the regurgitation that is slowly getting worse.
Medicine may also help steady severe disease for a short time. It may be used to help the heart before surgery. A pump may also be needed to help the heart be ready for surgery.
Surgery
Valves that are causing severe problems or getting worse fast will need surgery. The valve will be fixed or replaced.
American Heart Association
National Heart, Lung, and Blood Institute
CANADIAN RESOURCES:
Canadian Cardiovascular Society
Heart and Stroke Foundation of Canada
American Heart Association
National Heart, Lung, and Blood Institute
CANADIAN RESOURCES:
Canadian Cardiovascular Society
Heart and Stroke Foundation of Canada
References
- Mitral regurgitation. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/mitral-regurgitation.
- Mitral valve regurgitation. CardioSmart—American College of Cardiology website. Available at: https://www.cardiosmart.org/topics/mitral-regurgitation.
- Problem: Mitral valve regurgitation. American Heart Association website. Available at: http://www.heart.org/en/health-topics/heart-valve-problems-and-disease/heart-valve-problems-and-causes/problem-mitral-valve-regurgitation.
- Uretsky, S., Argulian, E., et al. Use of cardiac magnetic resonance imaging in assessing mitral regurgitation: current evidence. J Am Coll Cardiol, 2018; 71 (5): 547-563.
Contributors
- Michael J. Fucci, DO, FACC
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