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Nephrotic Syndrome—Child

  • Cynthia M. Johnson, MA
Publication Type:


Nephrotic Syndrome—Child



Nephrotic syndrome is a group of changes affecting the kidneys. These may involve:

  • High amounts of protein in the urine
  • Swelling in the body—mainly in the feet and legs
  • Low levels of a protein called albumin in the blood
  • High cholesterol in the blood
Anatomy of the Kidney.

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The kidneys filter waste from the blood and make urine. Nephrotic syndrome happens when tiny filters in the kidneys leak too much protein into urine.

In most children, the cause is not known. In others, the most common cause is minimal change disease. This is damage to the filters due to things like infections, tumors, allergic reactions, and certain medicines.

Other health problems that can damage the kidneys can also lead to nephrotic syndrome.

Risk Factors

Nephrotic syndrome can affect children of any age. It is more common in boys. Other things that may raise the risk are:

  • Health problems that can damage the kidneys
  • Taking certain medicines
  • Certain infections, such as cytomegalovirus and HIV


Problems may be:

  • Lack of energy
  • Pale skin
  • Lack of hunger
  • Foamy urine
  • Swelling of feet, ankles, and legs and less often the belly, hands, and face
  • Weight gain
  • Mood changes
  • Breathing problems

There may be times when nephrotic syndrome does not cause problems. There may be other times when symptoms are more active.


The doctor will ask about your child’s symptoms and health history. A physical exam will be done. It will check for swelling in the body. This may be enough to suspect the diagnosis.

Blood and urine tests will be done to look at protein levels. This can confirm the diagnosis.


Any underlying causes will need to be treated. Care will be given by a doctor who treats the kidneys.

Nephrotic syndrome often goes away on its own. Some treatment options are:


There are current guidelines to prevent nephrotic syndrome.

Dietary Changes

Salt, fats, cholesterol, and fluids may need to be limited. This can help ease problems, such as swelling.

Dietary Changes

Salt, fats, cholesterol, and fluids may need to be limited. This can help ease problems, such as swelling.


Medicine may be given to:

  • Control the immune system and improve kidney function—corticosteroids
  • Remove extra fluid—diuretics
  • Lower blood pressure

Medicines that may be causing harm to the kidneys may also need to be stopped or changed.





  • Childhood nephrotic syndrome. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: https://www.niddk.nih.gov/health-information/kidney-disease/children/nephrotic-syndrome-children?dkrd=/health-information/kidney-disease/children/childhood-nephrotic-syndrome.
  • Childhood nephrotic syndrome. National Kidney Foundation website. Available at: https://www.kidney.org/atoz/content/childns.
  • Nephrotic syndrome. Kids Health—Nemours Foundation website. Available at: http://kidshealth.org/en/parents/nephrotic-syndrome.html.
  • Nephrotic syndrome in children. Children’s Hospital of Philadelphia website. Available at: http://www.chop.edu/conditions-diseases/nephrotic-syndrome-children.
  • Nephrotic syndrome in children. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/nephrotic-syndrome-in-children-21.


  • Kari Kuenn, MD
Last Updated:

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.