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Symptoms of Chronic Kidney Disease

  • Cynthia M. Johnson, MA
Publication Type:

Condition InDepth

Symptoms of Chronic Kidney Disease

Chronic kidney disease (CKD) does not cause problems in early stages. As it worsens, it may result in:

  • Feeling weak or tired
  • Trouble sleeping
  • Swelling of the feet and ankles
  • Lack of hunger
  • Passing urine more often, especially at night
  • Muscle cramps when sleeping
  • Nausea
  • Itching
  • Breathing problems
  • A metal taste in the mouth
  • Chest pain
  • Confusion
  • Hiccups
  • Irritability
  • Problems focusing
  • Lower sex drive
  • Menstrual problems
  • Numbness and tingling in the hands and feet


  • Chronic kidney disease. Merck Manual Professional Version website. Available at: https://www.merckmanuals.com/professional/genitourinary-disorders/chronic-kidney-disease/chronic-kidney-disease.
  • Chronic kidney disease. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: https://www.niddk.nih.gov/health-information/kidney-disease/chronic-kidney-disease-ckd.
  • Chronic kidney disease (CKD). Family Doctor—American Academy of Family Physicians website. Available at: https://familydoctor.org/condition/chronic-kidney-disease-ckd.
  • Overview of chronic kidney disease (CKD) in adults. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/overview-of-chronic-kidney-disease-ckd-in-adults.


  • Mark S. Itzkowitz, MD, JD
Last Updated:

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.