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Symptoms of End-stage Renal Disease (ESRD)

  • Cynthia M. Johnson, MA
Publication Type:

Condition InDepth

Symptoms of End-stage Renal Disease (ESRD)

Symptoms may change or worsen as chronic kidney disease reaches this stage. Common ESRD symptoms may be:

  • Pain—May be caused by the disease, its care, or other health problems. It may be felt all over the body or in certain places, such as the bones, muscles, nerves, or belly.
  • Feeling weak and tired
  • Lack of hunger
  • Weight loss
  • Itchy skin
  • Breathing problems
  • Problems sleeping
  • Difficulty with thinking and focus
  • Swelling—Can happen in the face, hands, legs, ankles or feet
  • Nausea and vomiting
  • Depression
  • Problems passing urine


  • Choosing a treatment for kidney failure. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: https://www.niddk.nih.gov/health-information/kidney-disease/kidney-failure/choosing-treatment.
  • Chronic kidney disease (CKD) in adults. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/chronic-kidney-disease-ckd-in-adults.
  • Complications of chronic kidney disease. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/complications-of-chronic-kidney-disease.
  • What is kidney failure? National Kidney Foundation website. Available at: https://www.kidney.org/atoz/content/KidneyFailure.


  • Mark S. Itzkowitz, MD, JD
Last Updated:

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.